![]() Modern models of active inference and the free energy principle (FEP) may shed some light on these processes. This is a process that may constitute an attempt at minimizing the excess of free energy present in psychosis. These data are particularly interesting when considered from the perspective of the psychoanalytic understanding of the positive symptoms of psychosis, most notably the Freudian hypothesis of delusions as an “attempt at recovery.” Combining the data from research in neuroimaging of schizophrenia patients with the Freudian hypothesis, we propose considering the hyperactivity of the DMN as a consequence of a process of massive reassociation of traces occurring in schizophrenia. Studies have evidenced the existence of hyperactivity in this network in schizophrenia patients, particularly among those for whom a positive symptomatology is dominant. Anomalies in the functioning of the DMN have been observed in schizophrenia. In this article we study one significant clinical application of this interdisciplinary dialogue by looking at the role of the DMN in the psychopathology of schizophrenia. The pattern of cerebral activity at resting state and the identification of a default mode network (DMN), a network of areas whose activity is detectable at baseline conditions by neuroimaging techniques, offers a promising field of research in the dialogue between psychoanalysis and neuroscience. The economic conceptualization of Freudian metapsychology, based on an energetics model of the psyche's workings, offers remarkable commonalities with some recent discoveries in neuroscience, notably in the field of neuroenergetics. 10Département de Psychiatrie, Faculté de Médecine, Université de Genève, Geneva, Switzerland.9Brain Mind Institute, Swiss Federal Institute of Technology Lausanne, Lausanne, Switzerland. ![]() 8Division of Biological and Environmental Sciences and Engineering (BESE), King Abdullah University of Science and Technology, Thuwal, Saudi Arabia.7École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.5Agalma Foundation Geneva, Geneva, Switzerland.4Ecole Pratique des Hautes Etudes, Université Paris Sciences et Lettres, Paris, France.3Université de Caen Normandie, Caen, France.2Centre Hospitalier Universitaire de Caen, Caen, France.1INSERM U1077 Neuropsychologie et Imagerie de la Mémoire Humaine, Caen, France.Magistretti 5,8,9 and Francois Ansermet 5,10 Jessica Tran The 1,2,3,4,5,6 *, Jean-Philippe Ansermet 7, Pierre J.
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